Purinergic Signalling

Aims & Scope

Nucleotides and nucleosides are primitive biological molecules that were utilized early in evolution both as intracellular energy sources and as extracellular signalling molecules.

ATP was first identified as a neurotransmitter and later as a co-transmitter with all the established neurotransmitters in both peripheral and central nervous systems.

Four subtypes of P1 (adenosine) receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of P2Y G protein-coupled receptors have currently been identified.

Since P2 receptors were first cloned in the early 1990’s, there is clear evidence for the widespread distribution of both P1 and P2 receptor subtypes in neuronal and non-neuronal cells, including glial, immune, bone, muscle, endothelial, epithelial and endocrine cells.

View Aims & Scope

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Metrics & Ranking

Impact Factor

Year	Value
2025	2.4
2024	3.00

SJR (SCImago Journal Rank)

Year	Value
2024	0.825

Quartile

Year	Value
2024	Q2

h-index

Year	Value
2024	70

Journal Rank

Year	Value
2024	6498

Journal Citation Indicator

Year	Value
2024	495

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Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

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Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology and Neuroscience, designed to support cutting-edge academic discovery.

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Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• Cellular function and molecular structure of ecto-nucleotidases

  Citation: 878

  Authors: Herbert, Matthias, Norbert

• The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance

  Citation: 777

  Authors: Simon C., Jean, Herbert

• ATP synthesis and storage

  Citation: 506

  Authors: Massimo, Simone, Alessandro, Elena, Jan M., Angela, Carlotta, Saverio, Sonia, Federica, Mariusz R., Paolo

• Alkaline Phosphatases

  Citation: 500

  Authors: José Luis

• Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade

  Citation: 430

  Authors: Rodrigo A.

• Physiological roles for ecto-5’-nucleotidase (CD73)

  Citation: 421

  Authors: Sean P., Holger K., Tobias, Linda F.

• P2 receptors in cardiovascular regulation and disease

  Citation: 293

  Authors: David, Geoffrey

• Purinergic signalling and immune cells

  Citation: 272

  Authors: Geoffrey, Jean-Marie

• Purinergic signalling and cancer

  Citation: 269

  Authors: Geoffrey, Francesco

• Vesicular and conductive mechanisms of nucleotide release

  Citation: 251

  Authors: Eduardo R.

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