Journal of Medicinal Chemistry

Aims & Scope

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

Some specific areas that are appropriate include the following: -Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. -Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR).

Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication. -Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. -Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition. -Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge. -Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules. -Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds.

This may include design, synthesis, and evaluation of novel types of prodrugs. -Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

View Aims & Scope

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Metrics & Ranking

Impact Factor

Year	Value
2025	6.8
2024	6.80

SJR (SCImago Journal Rank)

Year	Value
2024	1.801

Quartile

Year	Value
2024	Q1

h-index

Year	Value
2024	314

Journal Rank

Year	Value
2024	1739

Journal Citation Indicator

Year	Value
2024	20078

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Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar
• Web of Science

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Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology and Pharmacology, Toxicology and Pharmaceutics, designed to support cutting-edge academic discovery.

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Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy

  Citation: 8339

  Authors: Richard A., Jay L., Robert B., Thomas A., Jasna J., Daniel T., Matthew P., Eric H., Mee, Jason K., David E., Perry, Peter S.

• Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

  Citation: 6581

  Authors: Daniel F., Stephen R., Hung-Yuan, Brian R., Keith W., Kenneth D.

• Extra Precision Glide:  Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes

  Citation: 5878

  Authors: Richard A., Robert B., Matthew P., Leah L., Jeremy R., Thomas A., Paul C., Daniel T.

• Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

  Citation: 5368

  Authors: Edon, David T., Jon T.

• Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening

  Citation: 4423

  Authors: Thomas A., Robert B., Richard A., Hege S., Leah L., W. Thomas, Jay L.

• pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

  Citation: 3947

  Authors: Douglas E. V., Tom L., David B.

• Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

  Citation: 3648

  Authors: Frank, Jack, Christine

• New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

  Citation: 3367

  Authors: Jonathan B., Georgina A.

• The Many Roles for Fluorine in Medicinal Chemistry

  Citation: 3324

  Authors: William K.

• Applications of Fluorine in Medicinal Chemistry

  Citation: 3102

  Authors: Eric P., Kyle J., Matthew D., David J., Nicholas A.

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