Drug Metabolism and Disposition

Aims & Scope

An important reference for all pharmacology and toxicology departments, Drug Metabolism and Disposition (DMD) is also a valuable resource for medicinal chemists involved in drug design and biochemists with an interest in drug metabolism, expression of drug metabolizing enzymes, and regulation of drug metabolizing enzyme gene expression.

Articles provide experimental results from in vitro and in vivo systems that bring you significant and original information on metabolism and disposition of endogenous and exogenous compounds, including pharmacologic agents and environmental chemicals.

View Aims & Scope

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Metrics & Ranking

Impact Factor

Year	Value
2025	4
2024	4.40

Journal Rank

Year	Value
2024	3334

Journal Citation Indicator

Year	Value
2024	1753

SJR (SCImago Journal Rank)

Year	Value
2024	1.245

Quartile

Year	Value
2024	Q1

h-index

Year	Value
2024	198

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Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar
• Web of Science
• Medline
• Embase

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Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Pharmacology, Toxicology and Pharmaceutics, designed to support cutting-edge academic discovery.

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Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

  Citation: 1537

  Authors: Thomas, Faye, Mark H., John E., U. Kristina

• DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

  Citation: 824

  Authors: J. Andrew, Ruth, Barry C., Dennis A., Susan, Theunis C., Vincent, Jeffrey R., Simon E.

• ACETAMINOPHEN-INDUCED HEPATOTOXICITY

  Citation: 764

  Authors: Laura P., Philip R., Jack A.

• Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

  Citation: 753

  Authors: R. Scott

• THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”

  Citation: 738

  Authors: Mary F., Heather L., Shana S., Robert L., Allan E., Darryl C.

• THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE

  Citation: 670

  Authors: Thorir D., John T., Heidi J., Volker, Lawrence, Scott, John, S. Peter, Gerald, Lan, Gondi, James, R. Scott, Stanley, Amy, Anita, Fred, John T., Donald, Jose M., John, Steven A.

• Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

  Citation: 661

  Authors: Miho, Yumi, Tomoko, Katsunobu, Nagy A., Osamu, Toshihiko, Atsushi

• COMPARISON OF PRIMARY HUMAN HEPATOCYTES AND HEPATOMA CELL LINE HEPG2 WITH REGARD TO THEIR BIOTRANSFORMATION PROPERTIES

  Citation: 642

  Authors: Stefan, Frank, Augustinus

• EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS

  Citation: 576

  Authors: Caroline, Amélie, Denise, Typhen, Sophie, Fabrice, Christiane, André

• The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans

  Citation: 556

  Authors: Stefan, Thomas, Eva, Joachim, Willy

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