Cell Chemical Biology

Aims & Scope

Cell Chemical Biology is a Cell Press journal publishing research and review content of exceptional interest for the chemical biology community.

Launched in 1994 under the title Chemistry & Biology, the journal was the first to recognize the growing importance of investigations done at the interface of chemistry and biology, and its mission has always been to support and promote chemical biology and conversation and collaboration between chemical and life sciences.

Cell Chemical Biology strongly encourages submission of articles that provide significant conceptual advancement of broad general interest to both chemists and biologists.

We are especially interested in papers that combine the use of chemical tools to perturb, visualize, and measure biological systems and properties and offer unique insights into molecular mechanism or physiology.

We also encourage submissions that are focused on method development for basic life sciences or that have practical impact of either clinical or biotechnological nature.

Some additional types of research that we consider within our scope are studies of metabolism and physiology; enzyme mechanism and natural product biosynthesis; generation, distribution, and function of small molecule-protein conjugates such as post-translational modifications; mechanism of resistance to small molecules by viruses/bacteria/cancer cells/organisms; intra- and intercellular and intra- and interspecies communication mediated by small molecules; and chemical biology of lipids, sugars, and nucleic acids.

Finally, large-scale studies enabled by the use of chemistry-based technology, such as proteomics, lipidomics, metabolomics, and glycomics, are also within our scope, as well as synthetic and systems biology work when inspired and supported by chemical tools or aimed at engineering biological systems to perform a new type of chemical transformation.

View Aims & Scope

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Metrics & Ranking

Impact Factor

Year	Value
2025	7.2
2024	6.60

SJR (SCImago Journal Rank)

Year	Value
2024	2.659

Quartile

Year	Value
2024	Q1

h-index

Year	Value
2024	215

Journal Rank

Year	Value
2024	878

Journal Citation Indicator

Year	Value
2024	2895

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Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar
• Web of Science
• Medline
• Embase

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Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology and Pharmacology, Toxicology and Pharmaceutics, designed to support cutting-edge academic discovery.

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Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State

  Citation: 854

  Authors: Leslie, Pin-Joe, Milton, Jennifer Yinuo, Giovanni C., Amy, Carl C., Kevin, Gary J., Daniel K., James A., Scott J.

• Targeting Metabolism for Cancer Therapy

  Citation: 772

  Authors: Alba, Dan Y., Matthew G.

• Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

  Citation: 749

  Authors: Daniel P., Blake E., George M., Alexandru D., John, Saul, Jing, Brian D., Alexey, Craig M.

• Autophagy-Dependent Ferroptosis: Machinery and Regulation

  Citation: 650

  Authors: Jiao, Feimei, Guido, Daniel J., Rui, Daolin

• Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

  Citation: 577

  Authors: Yan, Hui, Jacob D., Fereshteh, Hengrui, Lewis M., Koji, Owen A., Brent R.

• The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

  Citation: 553

  Authors: George M., Blake E., Ashton C., Saul, Daniel C., Daniel P., Momar, Hanqing, Yimin, Jing, Andrew P., John, Craig M.

• Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages

  Citation: 519

  Authors: Cornelius Y., Marian C., Daniel A.

• Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery

  Citation: 426

  Authors: Fleur, Salo N., Krijn K., Emile E.

• A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

  Citation: 392

  Authors: Hai-Tsang, Dennis, Joshiawa, Guang, Ellen L., Zainab M., Dennis L., Joong-Heui, Eunhwa, Jaebong, Kun, Hwan Geun, James D., Ying, Steven P., Eric S., James E., Li, Nathanael S.

• PROTACs: An Emerging Therapeutic Modality in Precision Medicine

  Citation: 383

  Authors: Dhanusha A., Craig M.

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