Bioorganic and Medicinal Chemistry Letters

Aims & Scope

Bioorganic & Medicinal Chemistry Letters publishes research communications of outstanding significance and timeliness on topics at the interface of chemistry and biology, together with invited concise review articles.

The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging advances and concepts in these fields.

The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents.

The journal continues to be a major forum for the first publication of new chemical entities prior to them entering clinical trials.

The Journal welcomes papers on: -the medicinal chemistry and associated biology (including target identification and validation) of established or new disease targets -the reporting of the discovery, design or optimization of potent new compounds or biological agents -the analysis and discussion of structure-activity relationships and pharmacological issues relevant to drug design and action using in vitro and in vivo models, including the use of computational techniques when closely linked to experimental data -the reporting of "first-in-class" new therapeutic compounds -the chemical biology or bioorganic/bioinorganic chemistry that significantly advances knowledge of a biological mechanism -methodological advances that are chemistry-based and which significantly impact on medicine or biology -the preparation and examination of biotherapeutics for the treatment of pathophysiological disease states -the development of materials for specific therapeutic targeting

View Aims & Scope

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Metrics & Ranking

Impact Factor

Year	Value
2025	2.2
2024	2.50

Journal Rank

Year	Value
2024	12156

Journal Citation Indicator

Year	Value
2024	2992

SJR (SCImago Journal Rank)

Year	Value
2024	0.472

Quartile

Year	Value
2024	Q2

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Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar
• Web of Science
• Embase

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Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology, Chemistry and Pharmacology, Toxicology and Pharmaceutics, designed to support cutting-edge academic discovery.

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Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• The use of spirocyclic scaffolds in drug discovery

  Citation: 913

  Authors: Yajun, Colin M., Suresh B.

• Physiochemical drug properties associated with in vivo toxicological outcomes

  Citation: 838

  Authors: Jason D., Julian, David A., Simon, Gary A., Rajesh V., Edmund, Yvette M., Michael E., Richard W., Nigel, Enoch, Teresa, Jens, Travis, Larry, Yao

• The SARS-CoV-2 main protease as drug target

  Citation: 649

  Authors: Sven, Christoph

• Carbonic anhydrase inhibitors

  Citation: 589

  Authors: Claudiu T.

• Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

  Citation: 571

  Authors: Julian, Mark, Shaowu, Amy A., Lawrence R., Louis, Janice M., Yu-Ting, Louis, Ross L.

• Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

  Citation: 557

  Authors: Nicholas K., Andrew S., David, Peter

• Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

  Citation: 511

  Authors: Ashley R., Mathieu, Hyun Seop, Craig M.

• Antioxidant activity of water-soluble chitosan derivatives

  Citation: 509

  Authors: Wenming, Peixin, Qing

• Studies leading to the identification of ZD1839 (iressaâ„¢): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer

  Citation: 479

  Authors: Andrew J, Keith H, Walter, Andrew A, Jeffrey J, Mark P, James R, Susan E, Brenda J, Lynn, Lianne, Laura

• Rynaxypyrâ„¢: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator

  Citation: 452

  Authors: George P., Thomas M., Thomas P., John H., Daniel, Lindsey, Cheryl A., Christine M., Ben K., Kenneth A., J. Gary, Christopher E., Eric A.

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