Toxicology in Vitro

Aims & Scope

Toxicology in Vitro publishes original research papers, reviews and workshop reports focusing on the application and use of in vitro and in silico systems for toxicological evaluations (collectively described as New Approach Methodologies (NAM)).

This includes the utilisation or the development of NAMs for assessing the potential adverse effects of chemicals for human safety assessment.

In vitro techniques include primary cells, tissue slices, cell lines and stem cells (adult, embryonic and induced Pluripotent cells) or subcellular preparations thereof.

Our journal strongly supports the Reduction, Refinement and Replacement (3R) of animals in toxicology evaluations.

View Aims & Scope

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Metrics & Ranking

Impact Factor

Year	Value
2025	2.7
2024	2.60

SJR (SCImago Journal Rank)

Year	Value
2024	0.718

Quartile

Year	Value
2024	Q2

h-index

Year	Value
2024	134

Journal Rank

Year	Value
2024	7859

Journal Citation Indicator

Year	Value
2024	1593

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Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar
• Web of Science
• Embase

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Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Medicine and Pharmacology, Toxicology and Pharmaceutics, designed to support cutting-edge academic discovery.

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Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• In vitro toxicity of nanoparticles in BRL 3A rat liver cells

  Citation: 1652

  Authors: S.M., K.L., J.M., K.T., J.J.

• Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells

  Citation: 739

  Authors: Soohee, Ji Eun, Jinhee, Kyu-Hyuck, Kwangsik, Jongheop, Doug-Young

• Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism

  Citation: 691

  Authors: Young Jin, Xiaodong, Marilyn E.

• Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism

  Citation: 632

  Authors: Eun-Jung, Jongheop, Younghun, Kyunghee, Kwangsik

• Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast Saccharomyces cerevisiae

  Citation: 541

  Authors: Kaja, Angela, Henri-Charles, Anne

• Optimization of chemically defined cell culture media – Replacing fetal bovine serum in mammalian in vitro methods

  Citation: 494

  Authors: J., D., K., Ã…., P., L.E., T., J., A., M.L., G.

• ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells

  Citation: 458

  Authors: Ritesh K., Vyom, Alok K., Shashi, Sarwat, Alok

• Comparison of alamar blue and MTT assays for high through-put screening

  Citation: 455

  Authors: R, Y, L, R, P

• Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells

  Citation: 424

  Authors: Baher, Stephania A.

• SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study

  Citation: 413

  Authors: Françoise, Elodie, Jean-Claude, Jean-Luc, Isabelle, Imène-Sarah, Bernard, Ambre, Agnes, Pascal, Claude, Pierre, Hervé

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