Journal of Gene Medicine

Aims & Scope

The aims and scope of The Journal of Gene Medicine include cutting-edge science of gene transfer and its applications in gene and cell therapy, genome editing with precision nucleases, epigenetic modifications of host genome by small molecules, siRNA, microRNA and other noncoding RNAs as therapeutic gene-modulating agents or targets, biomarkers for precision medicine, and gene-based prognostic/diagnostic studies.

Key areas of interest are the design of novel synthetic and viral vectors, novel therapeutic nucleic acids such as mRNA, modified microRNAs and siRNAs, antagomirs, aptamers, antisense and exon-skipping agents, refined genome editing tools using nucleic acid /protein combinations, physically or biologically targeted delivery and gene modulation, ex vivo or in vivo pharmacological studies including animal models, and human clinical trials.

Papers presenting research into the mechanisms underlying transfer and action of gene medicines, the application of the new technologies for stem cell modification or nucleic acid based vaccines, the identification of new genetic or epigenetic variations as biomarkers to direct precision medicine, and the preclinical/clinical development of gene/expression signatures indicative of diagnosis or predictive of prognosis are also encouraged.

View Aims & Scope

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Metrics & Ranking

Impact Factor

Year	Value
2025	2.2
2024	3.20

Journal Rank

Year	Value
2024	7934

Journal Citation Indicator

Year	Value
2024	719

SJR (SCImago Journal Rank)

Year	Value
2024	0.712

Quartile

Year	Value
2024	Q2

h-index

Year	Value
2024	102

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Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar
• Web of Science

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Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology, Medicine and Pharmacology, Toxicology and Pharmaceutics, designed to support cutting-edge academic discovery.

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Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis

  Citation: 1133

  Authors: Akin, Mini, Alexander M., Robert

• Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives

  Citation: 740

  Authors: Michael, Dagmar, Thomas

• Gene therapy clinical trials worldwide to 2017: An update

  Citation: 704

  Authors: Samantha L., Anais K., Ian E., Michael, Mohammad R.

• Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo

  Citation: 602

  Authors: Lionel, Ralf, Vanessa, Sebastian, Regina, Malgorzata, Ernst

• Gene therapy clinical trials worldwide to 2012 – an update

  Citation: 601

  Authors: Samantha L., Ian E., Michael L., Mohammad R., Jo

• Gene therapy clinical trials worldwide to 2007—an update

  Citation: 448

  Authors: Michael L., Mohammad R., Jo

• Polyethylenimine-mediated gene delivery: a mechanistic study

  Citation: 427

  Authors: Antoine, Christian, Emmanuel, Olivier

• Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer

  Citation: 392

  Authors: Sabine, Katharina, Silke, Carsten, Ernst, Manfred

• Mesenchymal stem cells home to injured tissues when co‐infused with hematopoietic cells to treat a radiation‐induced multi‐organ failure syndrome

  Citation: 364

  Authors: Alain, Jean Marc, Morad, Loic, Randell G., Johanna, Christelle, Frédérique, Emilie, François, Nicolas, Claire, Christelle, Jocelyne, Jade, Norbert Claude, Patrick, Dominique

• Side‐effects of a systemic injection of linear polyethylenimine–DNA complexes

  Citation: 314

  Authors: Patrice, Marie C., A., Jean‐Luc

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