Human Gene Therapy Methods

Aims & Scope

Human Gene Therapy (HGT) is the premier, multidisciplinary journal covering all aspects of gene therapy.

The Journal publishes important advances in DNA, RNA, cell and immune therapies, validating the latest advances in research and new technologies.

Established in 1990, HGT provides a prestigious forum for publishing scientific and clinical research, including ethical, legal, regulatory, social, and commercial issues, which enables the advancement and progress of therapeutic procedures leading to improved patient outcomes, and ultimately, to curing diseases.

HGT is published 12 times per year, including sections on Methods (product testing and development) and Clinical Development (regulatory review, toxicology and commercial development).

The journal also publishes a wide range of reviews, commentaries and editorials.

Complete coverage includes: Basic and clinical advances in gene therapy Delivery systems Cell therapy Immunotherapy Clinical genome editing Small nucleic acid therapeutics, including RNAi Clinical trials (including confirmatory or negative results) Improvements in vector developments Animal models Pre-clinical animal/in vitro studies to assess safety of gene and cell therapy products Clinical protocols Commercial development of gene and cell therapy products.

Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar

Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, Medicine and Pharmacology, Toxicology and Pharmaceutics, designed to support cutting-edge academic discovery.

Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• Universal Real-Time PCR for the Detection and Quantification of Adeno-Associated Virus Serotype 2-Derived Inverted Terminal Repeat Sequences

  Citation: 427

  Authors: Christine, Maren, Nadine, Martin, Christina, Ingrid, Hans, Ulrich, Andreas, Anja, Armin

• Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

  Citation: 299

  Authors: Vedell, Jakob A., Roger J., Thomas

• Absolute Determination of Single-Stranded and Self-Complementary Adeno-Associated Viral Vector Genome Titers by Droplet Digital PCR

  Citation: 148

  Authors: Martin, Mauricio R., Shu-Jen, James M.

• Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors

  Citation: 136

  Authors: Brenda, Shelley, Elton, MaryEllen, Denise, Antonius, Samuel, Seng H., Abraham, Catherine R.

• Comparative Analysis of Cesium Chloride- and Iodixanol-Based Purification of Recombinant Adeno-Associated Viral Vectors for Preclinical Applications

  Citation: 123

  Authors: Benjamin, Felix D., Wolfgang, Thorsten

• Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids

  Citation: 120

  Authors: Kyle, Jalish Mahmud, Thomas

• Dual Adeno-Associated Virus Vectors Result in Efficient<i>In Vitro</i>and<i>In Vivo</i>Expression of an Oversized Gene,<i>MYO7A</i>

  Citation: 111

  Authors: Frank M., Sanford L., Vince A., William W., Shannon E.

• Determination of Anti-Adeno-Associated Virus Vector Neutralizing Antibody Titer with an <i>In Vitro</i> Reporter System

  Citation: 104

  Authors: Amine, Christian, Sabrina, Laurence, Philippe, Federico

• Comparison of Different Suicide-Gene Strategies for the Safety Improvement of Genetically Manipulated T Cells

  Citation: 102

  Authors: Virna, Elisabetta, Brian, Sarah, Irene, Andrea, Ettore, Martin

• Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines

  Citation: 93

  Authors: Aziza P., Howard, Vanja, Nadejda, July, Stéphane, Alice, Sonia, Anne-Marie, Sophie, Rénald, Sven