Current Protocols in Nucleic Acid Chemistry

Aims & Scope

Sound and reproducible laboratory methods are the foundation of scientific discovery.

Yet, all too often, nuances that are critical for an experiment’s success are not captured in the primary literature but exist only as part of a lab’s oral tradition.

The aim of each Current Protocols title is to provide the clearest, most detailed and reliable step-by-step instructions for all protocols relevant to a given subject area.

Written by experts in the field and extensively edited to our exacting standards, the protocols include all of the information necessary to complete an experiment in the laboratory—introduction, materials lists with supplier information, detailed step-by-step procedures with helpful annotations, recipes for reagents and solutions, illustrative figures and information-packed tables.

Each article also provides invaluable discussions of background information, applications of the methods, important assumptions, key parameters, time considerations, and tips to help avoid common pitfalls and troubleshoot experiments.

Furthermore, Current Protocols content is thoughtfully organized by topic for optimal usage and to maximize contextual knowledge.

Quarterly issues allow Current Protocols in Nucleic Acid Chemistry to constantly evolve to keep pace with the newest discoveries and developments.

Current Protocols in Nucleic Acid Chemistry is the comprehensive resource for detailed protocols related to nucleosides, nucleotides, and nucleic acids.

CPNC brings together hundreds of core and cutting edge techniques for synthesis and analysis.

Synthesis protocols include characterization data needed to verify that the desired products are obtained.

Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar

Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology, Chemistry and Medicine, designed to support cutting-edge academic discovery.

Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• UV Melting of G‐Quadruplexes

  Citation: 135

  Authors: Jean‐Louis, Laurent

• Sequence, Stability, and Structure of G‐Quadruplexes and Their Interactions with Drugs

  Citation: 87

  Authors: Yuwei, Danzhou

• Thin‐Layer Chromatography

  Citation: 58

  Authors: C.L.F., D.J.

• RNA Secondary Structure Prediction

  Citation: 49

  Authors: David H., Douglas H., Michael

• Characterization of Quadruplex DNA Structure by Circular Dichroism

  Citation: 48

  Authors: Rafael, Robert D., Jonathan B.

• Column Chromatography

  Citation: 44

  Authors: C.L.F.

• Liquid‐Phase Oligonucleotide Synthesis: Past, Present, and Future Predictions

  Citation: 44

  Authors: Alejandro Gimenez, Yogesh S.

• Preparation of Gold Nanoparticle–DNA Conjugates

  Citation: 39

  Authors: T. Andrew

• Probing RNA Structure with Chemical Reagents and Enzymes

  Citation: 38

  Authors: William A., David R.

• A Status Update of Modified Oligonucleotides for Chemotherapeutics Applications

  Citation: 38

  Authors: Yogesh S.