Combinatorial Chemistry and High Throughput Screening

Aims & Scope

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research.

Original research articles and reviews in the following areas are of special interest to the readers of this journal: ● Target identification and validation ● Assay design, development, miniaturization and comparison ● High throughput/high content/in silico screening and associated technologies ● Label-free detection technologies and applications ● Stem cell technologies ● Biomarkers ● ADMET/PK/PD methodologies and screening ● Probe discovery and development, hit to lead optimization ● Combinatorial chemistry (e.g. small molecules, peptide, nucleic acid or phage display libraries) ● Chemical library design and chemical diversity ● Chemo/bio-informatics, data mining ● Compound management ● Pharmacognosy ● Natural Products Research (Chemistry, Biology and Pharmacology of Natural Products) ● Natural Product Analytical Studies ● Bipharmaceutical studies of Natural products ● Drug repurposing ● Data management and statistical analysis ● Laboratory automation, robotics, microfluidics, signal detection technologies ● Current & Future Institutional Research Profile ● Technology transfer, legal and licensing issues ● Patents

View Aims & Scope

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Metrics & Ranking

Impact Factor

Year	Value
2025	1.7
2024	1.60

SJR (SCImago Journal Rank)

Year	Value
2024	0.361

Quartile

Year	Value
2024	Q3

h-index

Year	Value
2024	73

Journal Rank

Year	Value
2024	14852

Journal Citation Indicator

Year	Value
2024	1071

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Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar
• Web of Science
• Medline
• Embase

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Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Chemistry, Computer Science, Medicine and Pharmacology, Toxicology and Pharmaceutics, designed to support cutting-edge academic discovery.

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Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• Privileged Structures: Applications in Drug Discovery

  Citation: 505

  Authors: R., K., S., J., D.

• Evaluation of the Antioxidant Potential of Natural Products

  Citation: 471

  Authors: Sang Kook, Zakaria H., HaSook, Lumonadio, Esperenza J.C., Rajendra G., A. Douglas, John M.

• Computational Methods in Developing Quantitative Structure-Activity Relationships (QSAR): A Review

  Citation: 325

  Authors: Arkadiusz, Tomasz, Jorge

• Recent Advances on Potentiometric Membrane Sensors for Pharmaceutical Analysis

  Citation: 306

  Authors: Vinod, Arunima, Shilpi, Barkha

• Label-Free Detection of Biomolecular Interactions Using BioLayer Interferometry for Kinetic Characterization

  Citation: 305

  Authors: Joy, Krista, Charles, Sae, Danfeng, Henrik, Jing, Pu, Bettina, Weilei, Ram, Lian-She, Donald, Greg, Michael, Kevin, Huddee, Tim, Juan, Michael, Janette, Scott, Robert, Hong

• Metalloproteinase Inhibitors for the Disintegrin-Like Metalloproteinases ADAM10 and ADAM17 that Differentially Block Constitutive and Phorbol Ester-Inducible Shedding of Cell Surface Molecules

  Citation: 293

  Authors: Andreas, Christian, Millard, Neil, Robert, D., M., J.

• On Various Metrics Used for Validation of Predictive QSAR Models with Applications in Virtual Screening and Focused Library Design

  Citation: 268

  Authors: Kunal, Indrani

• Diversity Among Microbial Cyclic Lipopeptides: Iturins and Surfactins. Activity-Structure Relationships to Design New Bioactive Agents

  Citation: 222

  Authors: Jean-Marc, Olivier, Francoise

• Antioxidants and Inflammatory Disease: Synthetic and Natural Antioxidants with Anti-Inflammatory Activity

  Citation: 186

  Authors: Athina, Antonios

• Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance

  Citation: 183

  Authors: James

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