Circulation: Cardiovascular Genetics

Aims & Scope

Circulation: Genomic and Precision Medicine considers all types of original research articles, including studies conducted in human subjects, laboratory animals, in vitro, and in silico.

Articles may include investigations of: clinical genetics as applied to the diagnosis and management of monogenic or oligogenic cardiovascular disorders; the molecular basis of complex cardiovascular disorders, including genome-wide association studies, exome and genome sequencing-based association studies, coding variant association studies, genetic linkage studies, epigenomics, transcriptomics, proteomics, metabolomics, and metagenomics; integration of electronic health record data or patient-generated data with any of the aforementioned approaches, including phenome-wide association studies, or with environmental or lifestyle factors; pharmacogenomics; regulation of gene expression; gene therapy and therapeutic genomic editing; systems biology approaches to the diagnosis and management of cardiovascular disorders; novel methods to perform any of the aforementioned studies; and novel applications of precision medicine.

Above all, we seek studies with relevance to human cardiovascular biology and disease.

Manuscripts are examined by the editorial staff and usually evaluated by expert reviewers assigned by the editors.

Both clinical and basic articles will also be subject to statistical review, when appropriate.

Provisional or final acceptance is based on originality, scientific content, and topical balance of the journal.

Decisions are communicated by email, generally within six weeks.

The editors will not discuss a decision about a manuscript over the phone.

All rebuttals must be submitted in writing to the editorial office.

Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar

Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology and Medicine, designed to support cutting-edge academic discovery.

Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• Epigenetic Signatures of Cigarette Smoking

  Citation: 771

  Authors: Roby, Allan C., Riccardo E., Luke C., Lindsay M., Pooja R., Weihua, Tao, Cathy E., Stella, Hortensia, Jennifer A., Jennifer A., Radhika, Paul, James S., Sonja, Sonia H., Allan F., Kurt, Jin, Devin M., Luigi, Wei, Ellen W., Jan, Megan L., Tianxiao, Chunyu, Michael M., Chen, Douglas P., Annette, Rui, Peter M., Naomi R., John M., Jingzhong, Carlos J., Nicholas J., Marguerite R., Degui, Myrto, Paolo, Srikant, André G., Albert, Joel, Elena, Lifang, Pantel S., Dena G., Andrew B., Stefania, Stephen T., Erin B., Alicia K., Torsten, Elisabeth B., Bruce M., Kent D., Sina A., Brenton R., Liming, Dawn L., George T., Zdenko, Kerry J., Karen N., Nona, Sharon L. R., David, Andrea A., Joyce B. J., Isabelle, Donna K., Ken K., Yongmei, Melanie, Ian J., Myriam, Daniel, Stephanie J.

• Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics

  Citation: 754

  Authors: Pasi, Antti J., Peter, Teemu, Mika

• Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease

  Citation: 637

  Authors: Maarten F., Robert, Sylvia, Tatiana, Yvan, Leon, Daniel R., Jan A., Stephane, Blanche

• Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

  Citation: 513

  Authors: Bruce M., Christopher J., Vilmundur, Kathryn L., Aaron R., Jerome I., André G., Tamara B., Jacqueline C.M., Eric

• Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage

  Citation: 480

  Authors: Yasuhide, Koh, Takahiro, Hitoo, Kazuya, Minako, Shin, Osamu, Yoji, Satoshi, Masao, Toshihiro, Toru, Takeshi

• Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family Members

  Citation: 409

  Authors: Judith A., Aditya, Cynthia A., Anneline S., Dennis, Crystal, Brittney, Ans C.P., Abhishek C., Bina, Douwe E., Paul G., Natasja M., Karin, Stefan L., Ihab R., Jeroen F., Stuart D., Maarten, Ryan J., Pieter A., Toon A., Harikrishna, Arthur A., Daniel P., J. Peter, Richard N., Hugh

• Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events

  Citation: 400

  Authors: Svati H., James R., Michael J., Robert D., David R., Carol, Jennifer, L. Kristin, Elizabeth R., Geoffrey S., Christopher B., William E.

• Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension

  Citation: 327

  Authors: Eric D., Lijiang, Charles, Erika, Alain, John A., Teresa, Pavel, Hyunjae R., Megha H., James, James E., Wendy K.

• Association Between Shortened Leukocyte Telomere Length and Cardiometabolic Outcomes

  Citation: 294

  Authors: Matthew J.J., Stephanie A., Matthias, Sonia S., Hertzel, Guillaume

• Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors

  Citation: 276

  Authors: Qiong, Anna, Abbas, Albert V., Nicole L., Ming-Huei, Daniel I., Thor, Gudny, Tamara B., Lenore, Michael, Dena, Dan E., Eric, Megan L., Man, W.H., Michel, Talin, Guo, Thomas, Bruce M., Michael, Shih-Jen, Martin G., Christopher J., Ashish, Cornelia M., Albert, Fernando, Bruno, Andre G., Guillaume, Alex N., Paul M., David S., Vilmundur, Jacqueline C., Caroline S., Josef