American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Aims & Scope

The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations.

Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.

View Aims & Scope

---

Metrics & Ranking

Impact Factor

Year	Value
2025	2.3
2024	2.20

SJR (SCImago Journal Rank)

Year	Value
2024	0.945

Quartile

Year	Value
2024	Q2

Journal Rank

Year	Value
2024	5311

Journal Citation Indicator

Year	Value
2024	1231

---

---

Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar
• Web of Science
• Embase

---

Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology and Medicine, designed to support cutting-edge academic discovery.

---

Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• Inflammatory processes in muscle injury and repair

  Citation: 961

  Authors: James G.

• Sample entropy analysis of neonatal heart rate variability

  Citation: 895

  Authors: Douglas E., Joshua S., M. Pamela, J. Randall

• Regulatory interactions between muscle and the immune system during muscle regeneration

  Citation: 882

  Authors: James G., S. Armando

• Biochemistry of exercise-induced metabolic acidosis

  Citation: 855

  Authors: Robert A., Farzenah, Daryl

• Vascular NAD(P)H oxidases: specific features, expression, and regulation

  Citation: 706

  Authors: Bernard, Roza E.

• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations

  Citation: 620

  Authors: Kevin C., Hannah J.

• Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

  Citation: 614

  Authors: Ingrid, Rudi

• Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology

  Citation: 563

  Authors: Jian-Mei, Ajay M

• Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system

  Citation: 549

  Authors: Andrej A.

• Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values

  Citation: 536

  Authors: Julie, Aalia, Michael D.

---