Alternatives to Laboratory Animals

Aims & Scope

ATLA is a peer-reviewed journal, intended to cover all aspects of the development, validation, implementation and use of alternatives to laboratory animals in biomedical research and toxicity testing.

In addition to the replacement of animals, it also covers work that aims to reduce the number of animals used and refine the in vivo experiments that are still carried out.

The journal publishes original research papers, review articles, letters, comments and book reviews.

It is of relevance to research scientists, academics, and those involved in regulatory affairs or in the field of animal ethics.

The papers published commonly feature in vitro, ex vivo or in silico methods; surveys on the use of animals for education, research or testing purposes; humane teaching or medical training methods; and the optimisation and validation of novel or existing methods for use as non-animal alternatives.

View Aims & Scope

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Metrics & Ranking

Impact Factor

Year	Value
2025	3
2024	2.40

Journal Rank

Year	Value
2024	8339

Journal Citation Indicator

Year	Value
2024	232

SJR (SCImago Journal Rank)

Year	Value
2024	0.683

Quartile

Year	Value
2024	Q1

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Abstracting & Indexing

Journal is indexed in leading academic databases, ensuring global visibility and accessibility of our peer-reviewed research.

• Scopus
• Google Scholar
• Web of Science
• Embase

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Subjects & Keywords

Journal’s research areas, covering key disciplines and specialized sub-topics in Biochemistry, Genetics and Molecular Biology, Health Professions, Medicine and Pharmacology, Toxicology and Pharmaceutics, designed to support cutting-edge academic discovery.

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Most Cited Articles

The Most Cited Articles section features the journal's most impactful research, based on citation counts. These articles have been referenced frequently by other researchers, indicating their significant contribution to their respective fields.

• Current Status of Methods for Defining the Applicability Domain of (Quantitative) Structure-Activity Relationships

  Citation: 585

  Authors: Tatiana I., Andrew P., Tom, Romualdo, Mark T.D., Paola, Joanna S., Scott, Gilles, Carol A., Glenn, Nina, Grace Y., Roger, David W., Terry W., David T., Johannes J.M., Weida, Gilman, Chihae

• QSAR Applicability Domain Estimation by Projection of the Training Set in Descriptor Space: A Review

  Citation: 490

  Authors: Joanna, Nina, Tom

• A Multicompartmental Dynamic Computer-controlled Model Simulating the Stomach and Small Intestine

  Citation: 442

  Authors: Mans, Phillipe, Robert, Jos H.J. Huis in't

• The ECVAM International Validation Study on <i>In Vitro</i> Embryotoxicity Tests: Results of the Definitive Phase and Evaluation of Prediction Models

  Citation: 282

  Authors: Elke, Horst, Gabriele, Andrea, Nigel, Aldert, Madeleine, Nicole, Hannele, Francoise, Susanne, Klaus

• Validation of the Embryonic Stem Cell Test in the International ECVAM Validation Study on Three <i>In Vitro</i> Embryotoxicity Tests

  Citation: 265

  Authors: Elke, Horst, Gabriele, Ingeborg, Andrea, Nicole, Susanne, Klaus

• Chicken Egg Yolk Antibodies (IgY-technology): A Review of Progress in Production and Use in Research and Human and Veterinary Medicine

  Citation: 257

  Authors: Rüdiger, Esteban Gutierrez, Rodolfo, Pablo Anibal, Joanna, Horacio Raul

• Guidance on Good Cell Culture Practice

  Citation: 250

  Authors: Sandra, Michael, Gerard, John, Gerhard, Thomas, Robert, Otto-Wilhelm, Anna, Leonard, Glyn, William

• A Gold Standard Publication Checklist to Improve the Quality of Animal Studies, to Fully Integrate the Three Rs, and to Make Systematic Reviews More Feasible

  Citation: 236

  Authors: Carlijn R., Marlies, Merel

• The Use of Fetal Bovine Serum: Ethical or Scientific Problem?

  Citation: 205

  Authors: Carlo E. A., Jan B.F., Frans R., Vera

• The Use of Reconstructed Human Epidermis for Skin Absorption Testing: Results of the Validation Study

  Citation: 178

  Authors: Monika, Udo, Walter, Hans-Jürgen, Armin, Eleonore, Christine, Monika, Hennicke, Silke, Manfred, Hans Christian, Hans-Udo, Claus-Michael, Manfred, Annette, Christel, Frank, Frank, Maria K., Ulrich, Elisabeth, Sylvia, Horst, Alexander, Michaela

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